A year-old African-American female presented with nonbloody nipple discharge. Clinical and cytological examination of the discharge was normal. The mammography suggested pleomorphic calcification in the left breast. We removed the tumor tissue through lumpectomy and found that the mass was invasive ductal carcinoma.
The results of a randomized trial in 45 patients with primary invasive breast cancer showed that the drug -- which is currently used to treat arthritis and other painful conditions -- clearly induced an anti-tumor response at the molecular level. Celecoxib is a member of a class of drugs known as selective COX-2 inhibitors. These drugs directly target COX-2, an enzyme responsible for inflammation and pain. His group studied patients who were scheduled to have surgery to remove their cancer.